Fluticasone

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Fluticasone
Systematic (IUPAC) name
S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-
6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-
6,7,8,11,12,14,15,16-octahydrocyclopenta[a]
phenanthrene-17-carbothioate
Clinical data
AHFS/Drugs.com monograph
Pregnancy cat. C for Intranasal and Inhaled
Legal status POM (UK) ℞-only (US)
Routes Intranasal, Inhaled, Topical Cream or Ointment
Pharmacokinetic data
Bioavailability 0.51% (Intranasal)
Protein binding 91%
Metabolism Intranasal
Hepatic (CYP3A4-mediated)
Half-life 10 hours
Excretion Renal
Identifiers
CAS number 90566-53-3 N
80474-14-2 (propionate)
ATC code D07AC17 R01AD08 R03BA05
PubChem CID 5311101
DrugBank DB00588
ChemSpider 4470631 YesY
UNII CUT2W21N7U YesY
KEGG D07981 YesY
ChEBI CHEBI:5134 N
ChEMBL CHEMBL1201396 N
Chemical data
Formula C22H27F3O4S 
Mol. mass 444.508 g/mol
 N (what is this?)  (verify)

Fluticasone is a synthetic glucocorticoid.[1]

Both the furoate and propionate forms are used as topical anti-inflammatories:[2]

See also[edit]

References[edit]

  1. ^ Briggs, Gerald G.; Freeman, Roger K.; Yaffe, Sumner J. (2012), Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, Lippincott Williams & Wilkins, p. 600, ISBN 1451153597. 
  2. ^ Spratto, George R.; Woods, Adrienne L. (2012), Delmar Nurse’s Drug Handbook 2012, Cengage Learning, p. 748, ISBN 1111310653. 

source: http://en.wikipedia.org/wiki/Fluticasone

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